Nutrition Professor: How inflammation could age you | Philip Calder

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Published 2024-05-16
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Inflammation is a complicated topic. Short-term inflammation plays an essential role in fighting infections and healing injuries. But too much inflammation can be a catalyst for chronic ailments, like heart disease, type 2 diabetes, autoimmune disorders, rheumatoid arthritis, and obesity.

What we eat can influence our inflammatory responses and contribute to chronic, low-grade inflammation.

In today’s episode, Prof. Philip Calder helps us understand the science behind inflammation, how it impacts our health and what food has to do with it.

Philip is head of the School of Human Development and Health, as well as a Professor of Nutritional Immunology, in the Faculty of Medicine at the University of Southampton. He’s also an internationally recognised researcher on the metabolism and functionality of fatty acids. His work focuses on the roles of omega-3 fatty acids and the influence of diet and nutrients on immune and inflammatory responses.

Timecodes:
00:00 Introduction
01:10 Quickfire questions
03:00 The role of inflammation in immunity
05:40 Chronic inflammation and disease
08:49 How to measure inflammation
10:14 Should you worry about low-grade inflammation?
12:54 What causes blood vessel inflammation?
16:03 What creates the narrowing of blood vessels?
18:21 How inflammation can cause blood clots, heart attacks and strokes
20:13 Inflammation and aging
22:41 Inflammation and lifestyle factors
26:11 Obesity and inflammation
29:48 Muscle loss and inflammation (sarcopenia)
31:56 The impact of meals, sugar and fats on inflammation
36:04 Impact of diet inflammation
37:11 Why we all respond to food differently
42:25 What are omega-3s?
43:45 Anti-inflammatory foods
46:08 Health benefits of omega-3 fatty acids
48:24 Challenges with farmed salmon

Studies relevant to today's episode:
Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology?, published in British Journal of Clinical Pharmacology
Link: bpspubs.onlinelibrary.wiley.com/doi/10.1111/j.1365…

Omega-6 fatty acids and inflammation, published in PLEFA
Link: www.plefa.com/article/S0952-3278(18)30074-7/abstra…

Omega-3 Fatty Acids and Inflammatory Processes, published in Nutrients.
Link: www.mdpi.com/2072-6643/2/3/355

Health relevance of the modification of low-grade inflammation in ageing and the role of nutrition, published in Ageing Research Reviews
Link: www.sciencedirect.com/science/article/pii/S1568163…

Books:
Every Body Should Know This by Dr Federica Amati: amzn.to/4blJsLg
Food For Life by Prof. Tim Spector: amzn.to/4amZinu

Have feedback or a topic you'd like us to cover? Let us know here: gf6hx47iu5g.typeform.com/topicsuggestion

Episode transcripts are available: zoe.com/learn/category/podcasts

All Comments (21)
  • I went to the doctors concerned about inflammation 5 years ago. They were no help at all, even though I could have been on the path to diabetes. It's thanks to people like these guys that I figured it out and changed my health trajectory.
  • @sagism
    TLDR; - **Inflammation's Role**: Inflammation is not inherently harmful; it's a protective response to injury or infection, but can become problematic if unregulated or misplaced. - **Chronic Inflammation**: Long-term, improperly managed inflammation is associated with several diseases, such as arthritis, heart disease, type 1 diabetes, multiple sclerosis, and possibly some cancers. - **Dietary Influence**: Certain foods can trigger inflammation. For example, diets high in simple sugars and saturated fats can promote inflammation. - **Disease Connection**: Chronic inflammation can underlie conditions like obesity, heart disease, and type 2 diabetes by maintaining a persistent, low-grade inflammatory state. - **Nutritional Strategies**: Incorporating anti-inflammatory foods (e.g., foods high in omega-3 fatty acids, extra virgin olive oil, nuts, and fruits rich in antioxidants) can help manage inflammation. - **Personalized Nutrition**: Individual responses to foods vary, which can influence inflammation levels. Tailoring your diet to reduce inflammatory responses based on personal tolerances can be beneficial. - **Long-term Health**: Managing inflammation through diet and lifestyle choices is crucial for reducing the risk of inflammation-related diseases and promoting longevity and healthy aging. This advice emphasizes the significant impact of dietary choices on inflammation and overall health, suggesting that careful consideration of food intake can mitigate inflammation and its associated risks.
  • Thank you so much. In 70 years of doctors saying inflammation and many others waffling on even on You Tube..... You are the first person who actually explained what inflammation is.
  • Loved this, the interviewee was amazing at explaining things in such a clear, interesting way. More of him please!
  • @mikecolley-
    Apparently this is a huge subject area. Request more information on inflammation reduction in old age please. GREAT VIDEO!!! GREAT VIDEO
  • @karengrice2303
    Farmed salmon live in very polluted water because they are confined. It creates huge dead zones in the ocean. The fish are not able to move about like they would in the wild. I would recommend staying away from it. Sardines are a much better choice and are environmentally sustainable. By eating the whole sardine fish packed in olive oil, you take in a lot of nutrients from the skin, bone and flesh of the fish plus the benefits of the olive oil.
  • Nigel I can't tell you how much I appreciate your summarising of the information and clarifying questions, it takes me a while to process new information has someone with dyslexia & auditory processing, the way you interview is so helpful for me.
  • @artel6225
    Very enlightening, thank you both.
  • Thank you for answering a question I asked in a survey a while ago about what exactly inflammation within the body was. I could understand inflammation easily enough when it was due to an external injury but I now understand what general inflammation means. It was a great talk and good to know what is thought to cause it and ways that it might be limited through diet.
  • Great discussion to understand the phisiology of inflammation in our body, must be seen!
  • @gre55
    He explained it so clearly.... I love the zoe podcasts!
  • @DiugunLorac62
    I've heard from other doctors that having a big belly is a sign of inflammation.
  • @helenramsey9395
    Professor Calder I love you ❤️ And thank you Jonathan and the Zoe team. Sten Ekberg has a video on eating smaller fish like sardines and mackerel to avoid the heavy metals ‘Top 5 best fish you should never eat and 5 you must eat’ 👍
  • Going to a doctor in the uk is a complete waste of time, one has to take responsibility for one’s health more now than ever.
  • @creasedlinen
    A simply brilliant podcast, that actually takes the metabolic debate up stream (preventative/cause) to exactly where it should be - instead of downstream (treatment/effect)
  • @Natan9000
    Thank you so much for all the interesting and useful information. Btw why is the last chapter not in the chapter list 😅
  • @dianaknight600
    Great video .packed full of interesting,valuable information and advice .Thankyou