p53: Guardian of the Genome

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Published 2022-03-02

The tumour-suppressing protein called p53, also known as the guardian of the genome, protects our cells from cellular damage. Under cellular stress, p53 jumps into action, regulating gene expression to control DNA repair, cell division and cell death.

But, p53 malfunction is associated with a vast array of difficult to treat cancers, and these can arise either from mutations in the TP53 gene, or through an overabundance of a regulatory protein that keeps p53 inactive. Unfortunately, there are no catch-all drugs to tackle these types of cancer, but several combination therapies are undergoing research, offering hope for the future.

Read more in www.nature.com/collections/p53-outline

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All Comments (21)

@NSXTypeRGTRLM 2 years ago

While in medical school we had a security guard that would always give us a hard time even when we had our IDs on us. We lovingly called her p53.
@charvyr 2 years ago

I really liked the creative take on such a complex topic. Am thrilled how innovatively some of this protein's mechanisms are presented in here! Doesn't cover the whole story but anyone interested in learning the very basic might find it useful. As someone who submitted their thesis on p53, this was actually refreshing to watch.
@dehaya10 2 years ago

By far the best medical animation I've ever watched. Thanks to those who contributed. The adventure of understanding p53 continues...
@Electroblade360 2 years ago

I Really Liked The Idea Where The P53 Gene And The Cancer Fighting Super Duo Are Superheroes, Nice Touch
@rylaczero3740 2 years ago

Didn't hear a word. I was focused on the animation. Nice job.
@yurineri2227 28 days ago

YOW, the random sakuga at the fight scene at the end goes crazy tough 2:50 🗣🔥🔥
@elizabethelson1124 7 months ago

Thanks for simplyfying the topic in this way...and making it understandable 🙏😊
@hatibmuhamad585 2 years ago

Wow! the best science communication of the year so far
@negartoorany 2 years ago

it was really good! great job! please do more of these videos
@taariqparker2788 3 months ago

This is the most exciting/well explained video I've ever watched
@bhargavikulkarni6322 2 years ago

Amazingly visualized! Great work!
@holydiver588 2 years ago

Awesome video!
@paulaz.flaquer9570 2 years ago

Great animation!
@shubhambarik202 2 years ago

Great video
@TheSheekeyScienceShow 2 years ago

This is the protein i study :D
@armandoperezgutierrez1382 2 years ago

Good video
@user-bp8yg3ko1r 2 years ago

Nice art style, very well explained!
@user-tf9zh2jh6w 5 months ago

Miracle video
@shahirkhan6344 2 years ago

Great way of representation!
@lisadigangi2310 9 months ago

how would the drug selinexor work in regards to maintenence therapy for endometrial cancer? I'm trying to learn more for my mom who is in treatment for the disease now. We are beginning the selinexor clinical trial soon. I like to understand things so I can have questions ready for the dr. Thanks everyone. :)