Cholesterol & Risk of Death | New Evidence Emerges

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Published 2023-06-26
Are low cholesterol levels dangerous? Do they raise risk of death? A look at the evidence and its significance.

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Twitter: twitter.com/NutritionMadeS3
Animations: Even Topland @toplandmedia

References:
1.www.nature.com/articles/s41598-018-38461-y
2. www.bmj.com/content/371/bmj.m4266
3. www.sciencedirect.com/science/article/pii/S0002916…
4.cardiab.biomedcentral.com/articles/10.1186/s12933-…
www.nature.com/articles/s41591-020-0785-8
5. www.sciencedirect.com/science/article/pii/S1050173…
6. www.jacc.org/doi/full/10.1016/j.jacc.2008.06.036
7. journals.lww.com/co-lipidology/Abstract/2018/08000…
8. www.cochranelibrary.com/cdsr/doi/10.1002/14651858.…
9. www.ncbi.nlm.nih.gov/pmc/articles/PMC3437972/
10. academic.oup.com/ije/article/44/2/604/753171
11. www.sciencedirect.com/science/article/abs/pii/S146…
12. aspenjournals.onlinelibrary.wiley.com/doi/abs/10.1…
13. onlinelibrary.wiley.com/doi/full/10.1111/jdi.12698
14. www.sciencedirect.com/science/article/abs/pii/S147…
15. www.sciencedirect.com/science/article/abs/pii/S152…

Disclaimer: The contents of this video are for informational purposes only and are not intended to be medical advice, diagnosis, or treatment, nor to replace medical care. The information presented herein is accurate and conforms to the available scientific evidence to the best of the author's knowledge as of the time of posting. Always seek the advice of your physician or other qualified health provider with any questions regarding any medical condition. Never disregard professional medical advice or delay seeking it because of information contained in Nutrition Made Simple!.

#NutritionMadeSimple #GilCarvalho

0:00 Low cholesterol raises risk of death?
1:12 The U curve
2:20 BMI
3:09 Blood pressure
3:43 HbA1c
4:23 Disease lowers cholesterol
6:49 U curves are common
7:52 A thought experiment

All Comments (21)
  • I entirely agree with your assessment. As a biomedical scientist I measured thousands of serum cholesterol levels, and the low levels were very often in very sick people, often elderly and malnourished. I'm reminded of those claiming that excess acidity is the cause of all illness, whereas the truth is that acidosis, like a very low cholesterol, is the RESULT of illness, not the CAUSE.
  • @doctorpetrik
    I just came across your channel. This is cool. Your logic is flawless
  • Epic Gil. Because of science communicators like you, faith is being restored in the clinical guidelines and your viewers are leading healthier lives
  • @DrTomMD
    Similar issue with a recent paper on weight loss being associated with increased mortality where the confounding of disease driven weight loss was so obvious and yet it still hit the headlines that “weight loss can kill you“. Reverse causality. Another good video, Gil. Keep up the good work.
  • I find it chilling knowing that your videos NOW will probably wind up saving my life when I turn 60.
  • @BobPritchard
    Excellent video. Very helpful in understanding so many YouTube channels that state there's little wrong with high cholesterol. Thank you.
  • I appreciate your dedication to digging into this important issue.
  • This video would be helped by showing graphs from some of the better, double-blind studies that factor out the people with illness and show the curves where they "should" be. I'm skeptical without seeing those graphs. No dog in this fight, just want to actually see the better evidence.
  • @AndyMorrisArt
    Thank you for another straightforward explanation that even a high school dropout could understand. If I had only seen these graphs w/o your explanation, I probably would've thought "oh, I guess they found new evidence." Keep the good work going, a lot of us depend on you.
  • @kernjames
    Great video with lots of easy to understand information. You have a really great ability at explaining a complicated subject, and making it easy to understand.
  • This is truly fascinating and such a great explanation! Just goes to show, we shouldn’t take research data at face value out of context!
  • The issue I have with this is that is doesn’t seem to count the biggest killer, coronary heart disease, which is ‘typically’ associated with high cholesterol. Surely that should have had a huge impact on the the mortality rate but this doesn’t seem to generate even a blip on that data? That also should have a much higher impact in the data as the death from heart disease would generally be sudden and therefore the cholesterol state would be at its peak.
  • I am at 30, but I am mostly muscle. I have about 12% body fat. I always thought that BMI completely ignores athletes!
  • Interesting point in your video is that if your cholesterol is lower than expected, while you never tried to actively lower it,.... it means you probably have a disease you may not even be aware of. I know some people like that, though they are aware of the diseases. But their doctors tell them it's great. They don't tell them that their cholesterol is low because of their other diseases.
  • @doctorsTmd
    Hi Gil.I just came across your channel.I am very impressed.We need more people like you to cut through the confusion.We should connect.
  • @drmitofit2673
    As a physician for 35 years, this presentation is eye opening. Medical disease prevention criteria now seem backwards!
  • @yajy4501
    Thank you for what you do. There’s so much misinformation about nutrition floating around on YouTube. It’s a shame cause people are trying to better their health but getting misinformed by non experts or outright grifters. We need more professionals to do this kind of thing. 👍
  • @byamboy
    So crystal clear and to the point and brilliantly put! Thank you for this!
  • You make some of the best health related videos out there Gil! Huge thumbs up for this well put together presentation of the facts. Thank you!