276 ‒ Special episode: Peter on longevity, supplements, protein, fasting, apoB, statins, & more

In today's episode, we discuss: 0:00:55 - Overview of topics and previous episodes of a similar format 0:03:00 - The viability of living to 120 and beyond: some optimistic theories 0:13:21 - The potential of mTOR inhibition as a mid-life intervention, and longevity potential for the next generation 0:17:00 - A framework for thinking about geroprotective drugs and supplements in the context of a lack of aging biomarkers 0:27:10 - Supplements Peter takes and how his regimen has changed in the last year 0:39:41 - Pharmacologic strategies to lower ASCVD risk, the limitations of statins, nutritional interventions, and more 0:53:10 - Misnomers about cholesterol 1:07:07 - Why nutritional research is so challenging, some general principles of nutrition, and why Peter stopped doing prolonged fasts 1:06:17 - Optimizing protein intake 1:11:46 - Wearables for sleep and exercise, continuous glucose monitors (CGM), and a continuous blood pressure monitor on the horizon

Boy.. do we love Dr Peter Attia… the energy he exudes is beautiful. His articulation of the topics and speech delivery is short of arrogance.. thank you Doc and the organizers of this podcast

I love Dr Attia’s transparency & ability to synthesize very complicated topics. Thank you!! And I also love AG1 🎉

Very interesting video. I am 79 and active (I walk 5-10 miles almost every day, and exercise 2x a week, usually in tropical sunlight in Mexico and Florida) and no prescription drugs, and feel great. All my usual annual health exams are WNL. I do take NMN/TMG, 100mg ASA, an electrolyte drink, D3/K2, glycine, Taurine, AAKG and Metformin (my A1C is under 5 now.) I keep a roughly low carb diet - heavy on meat and vegetables, salmon and sardines. I try to get 1.2 gm/lb protein. Almost no sugar or refined flour most of the time. But live to enjoy life with my Mexican girlfriend! Living in Oaxaca Mexico most of the time, I am partial to Mezcal! And Mole! I occasionally take a week long drug holiday. I notice a reduction in energy and activity level. They return within a few days when I re-start. I sometimes (rarely) over indulge in excess sugar/flour when unique desserts are presented, or I just fall off the wagon. I try to get back on ASAP since I always feel bad after! A few moments of pleasure and a day or more of discomfort!. I am very scared of instances of questionable balance. I'm not sure the exercises to improve balance have been useful, but I do them! l hiked the Inca Trail 5 years ago but would not try again. I always like to have hand rails! I have also noticed a decrease of memory - can't remembers things I used to - but can usually recover those instances - names are most problematic. Analytical powers are still good - I do successful expert witness work for complex healthcare cases, and program in Python and MS SQL for analytics of data. I monitor walking and sleep with a smart watch. Sleep is variable but above average for my age. Still trying to optimize. I use KetoMojo to measure glucose and ketones daily. I am focused on health span, and agree to the concept marginal period -I hope less than a decade! Any time I have now is a bonus!. I want no tubes to keep me alive! I would love to see a discussion between Peter Attia and David Sinclair. I admire them both!

I care what you are doing NOW and that still after having your book, you have invested so much of your life taking care of yourself and others. Lets be honest you have lots of knowledge to share, and I from 🇨🇦 appreciate you and what you share. Thanks for the awesome BOOK!

The way I like to put it is instead of focusing on getting more years in my life, strive for more life in my years.

He’s always in a spicy mood!!! But his brilliance overshadows his personality.

thank you Peter...very edifying as always; I am a retired RN still visiting patients at home and it helps me a lot, for my own health and to give health advice.

Thank you for this episode. Peter - is is NOT a waste of time for some of us to hear you talk about ASCVD management. I live in NZ and the ASCVD management is 20yrs BEHIND. No ApoB or Lp(a) testing allowed unless self directed. If I obtain my own testing, the results are not understood my many “cardiologists” here. I struggle mate!

So appreciate this format...thanks, Dr. Attia and Company...

Love Dr. Attia's book. An excellent tool. Thank you!

I really appreciate the level of detail. Thank you.

Thanks so much for the info Dr. Attia! Hopefully all is well!

Thank you for this podcast. I found it informative to reply to the questions 👏💙 Need another one every 3/6 months pls. So we can compare ourselves as well🙏with many other health biomarkers as we think is right✨🌟💫💯

Yes - physical frailty IS “a big one”. In my late 60’s, not significantly overweight and have reasonably good markers re lipids etc. However during the last few years I have developed osteoarthritis of both knees - bone on bone and need two knee replacement surgeries. I know SO many people in this position. Apart from the pain on standing, this reduces one’s mobility and ability to exercise, especially aerobically - as a result I have lost a lot of fitness and feel that I have aged so much physically and psychologically - and often feel that I’m now an “old woman”.

The interviewer did a great job

Dr.Attia my favorite very practical and easy to understand about to be healthy and his voice so good and clear ♥️🇺🇸

peter is the best. would love a 6month or yearly update of what he takes, as he did with context for people with a brain to learn from

I am working hard to improve the quality of my years with science-based info as opposed to quantity of my years. I agree the science fiction out there about longevity is a lot. Ty for being spicy & informative.

HIIT 3 times a week has been the most beneficial thing I've done in years. Male, 65.