Migraine Pathophysiology - In depth

This is the most comprehensive explanation of migraines I have ever seen. Thank you for posting.

My god, this is stellar. I wish every GP; internist; neurologist; migraineur; medical science writer; and concerned friend, family member, and employer of a migraineur would see this video. Thank you so very much for creating and posting it.

I am not a scientist or a doctor. I have had migraines small, medium and occassionally large for one and half years. I have suffered from sinus infections and what I thought were allergy related issues (turns out I have no allergies). I have had MRIs, CT scans, seen a variety of doctors etc., etc. I have done my fair share of internet research. I work in a library. I love research. This might be the best explanation of migraine I have watched. Thank you!

I really don't even know how to thank you for creating this. It is profoundly well done - and even more impressive is you managed to simplify your message to make it understandable to anyone. I personally have had to live with the bullying that is often imposed on anyone with a "weird" illness. When you are not believed - it can make you insane. As if wrongly convicted of a crime - that has no DNA to support your story. Thank you so much - for creating this very clever presentation.

All of what you have explained in this video resonates with the development of my weekly childhood migraines to chronic migraines and the added debilitating experience of sleep disorder, blocked sinuses, depression and decreased mobility that comes with this disease. Thank you for this information.

This is a beautiful and profoundly informative video which I use to teach my osteopathy students about migraine. I would hug its creator if I could, just for the sheer quality of it.

My migraines started very specifically — when I worked 14-hr “plus” days in a very moldy building in the USAF from 9/11 onward for almost 3 yrs. many others in my bldg had the exact same symptoms - and dose-related (more hours in the bldg = worse ssx). I think the mycotoxins themselves were a big factor, but also the chronic inflammation caused by that constant high-dose long-term exposure. When I even smell staccybotrys and aspergillus now it almost instantly triggers a migraine - just the *smell*. It’s probably almost like a food aversion, but it’s my brain that’s reacting, not my stomach. The sinusitis and rhinitis also caused me to have severe sleep apnea that went undiagnosed (untreated) for several years. CPAP has helped a lot in terms of improving my fatigue, but the migraines are still relentless. I feel like I have brain damage from the mold itself and the hypoxia due to the 6yrs of untreated sleep apnea. It sucks!!! But all the neuro pathways, neurotransmitters, ganglia, etc discussed and modeled in this video sounds very accurate — it rings true very much — at least in terms of my migraine “pathogenesis”.

I’m a MIGRAINE Prisoner. I’m held captive by this pain from HELL. It’s debilitating! One day someone told me to mediate for the migraine to go away. I wanted to bitch slap him!!! I take prescription pills now and I’ll be taking an EEG next month. Often I think death is a relief from migraine. I know it’s extreme, but migraine suffers know what I’m taking about 😨😓😰😖

this video told me a lot more about migraines than neurologists i go to have told me. explained a lot and now i have a better understanding. thank you

voice is very refreshing, Calming! really helpful right now!

my migraines are always come along with anxiety and depression

What a great presentation! Thank you so much. I am glad I found this video. And thank gods, I found yoga therapy that helped me get rid of a chronic migraine that was enjoying its stay with me for almost 30years.

Thank you for this very informative Video with a soothing voice. I am a migraine sufferer ... sometimes getting 19 migraines a month. I feel like it’s a forgotten disease More research and help need to be done It’s a devastating disease that affects your ability to live life

this was the most thorough medical educational video i've ever seen. thank you!

Your relaxing voice is actually helping me relax during this migraine attack, thanks :)

I've sent this to all my care providers and people who love me. Got feedback from those who love me. It SO EXPLAINS all the symptoms I've had...and those my Grandmother had (chronic sinusitis) that didn't respond to treatments.

Thank you for mentioning every symptom i have had with migraine. I had the first when i was 18, i will never forget it. Since getting, C19 vac, mine have incresed so much and if you ever thought they could, have become worse. I speak back to front, can't write properly all of a sudden, get nausea, sometimes vomiting, cramps and diarrhea. I was diagnosed by GP. Wasted annual leave, so i didn't lose my job. They affect my whole body. Awful, just awful and most people think they are just headaches. No one explained to me that it was as diabolical as it felt. Until i seen this. Thank you so much. It is a life stealing condition.

Thank you for this. Such a complicated disease. No wonder it is taking forever to figure them out!

How does Sumatriptan work so totally, so quickly, and for any type of headache? I think a Nobel Prize is in order.

This is the best video on migraines yet, that I know of! Remarkable! Very informative and interesting, though quite nerve wracking!