A Brief Discussion of Hydroxychloroquine In COVID-19 (March 2020)

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Published 2020-04-09
This episode was recorded on and is current up to Friday March 27 2020
Heme Review Podcast (full audio) ▶️anchor.fm/chubbyemu
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Video by ‪@chubbyemu‬
What (Hydroxy)chloroquine Does To The Body ▶️   • What (Hydroxy)chloroquine Does To The...  

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Music by ‪@Lifeformed‬

Papers described in show:
- Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open- label non-randomized clinical trial. Gautret et. al. (Google Doc: drive.google.com/file/d/186Bel9RqfsmEx55FDum4xY_Il…, version as preprint submission: www.sciencedirect.com/science/article/pii/S0924857…)

- Statistical review of Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. zenodo.org/record/3724167#.Xn7LRy2ZPAy

- White NJ. The treatment of malaria. N Engl J Med. 1996;335(11):800.

- Warhurst DC et. al. Hydroxychloroquine is much less active than chloroquine against chloroquine-resistant Plasmodium falciparum, in agreement with its physicochemical properties. J Antimicrob Chemother. 2003;52(2):188. Epub 2003 Jul 1.

- Metal Ionophores- An Emerging Class of Anticancer Drugs. iubmb.onlinelibrary.wiley.com/doi/full/10.1002/iub…

- Chloroquine is a Zinc Ionophore. www.ncbi.nlm.nih.gov/pmc/articles/PMC4182877/#pone…

- Treatment of Severe Chloroquine Poisoning. www.ncbi.nlm.nih.gov/pubmed/15837026

#coronavirus #COVID19 #sarscov2

All Comments (21)
  • @HemeReview
    Hello! I wasn't sure to make this episode into a video because of the heavy clinical trials part in the second half. But here it is Hope you learn from and enjoy it, if you haven't heard it yet. New episode in the next few days
  • @Nellinator23
    Dr. Bernard's frustration was palpable in this one, and mirrored in my own mind. I'm not trained in medicine, but my training in chemistry taught me enough to know when a study stinks, and this would be laughable if the implications weren't so problematic. I love this kind of in-depth explanation of things, and look forward to hearing more of it.
  • @blessingo7449
    As a biophysical chemist, I always look forward to your in depth explanations! 😊😊
  • @silvereye731
    "This is obviously written by somebody who has never cared for patients" what a take down
  • @EriIaz
    Chubbyemu is the powerhouse of science! Seriously though, I couldn’t agree more with your critique. This research is an ideal example for us to learn why we need peer reviews no matter how urgent the situation is. Really sad to see bad science when we need good science so much.
  • @firerocket7343
    I understand that why you think the second half of the video may scare away some viewers, but that is the most important information the viewers should know about Hydroxychloroquine right now. Thank you for making this into a video.
  • @barbarahouk1983
    I appreciate your ability to teach to non physicians. It makes it easier for me, a physician to talk to my family (I am the first physician in my family).
  • @mobius8407
    When someone on the new says 'potential cure' doesn't mean it actually works. People need to stop taking unnecessary risks, but such people who do will always be there
  • @brandontoms5199
    Great video! If I'm gonna be completely honest, you are my favorite Youtuber and I love the way you explain these topics Keep it up! Love from Texas
  • @JonathanKanelis
    Hello, French citizen here. First of all, many thanks for your work: it is one of the most concise I have seen on the subject. Now despite all this number juggling, the doctor Raoult still continues his « trials » and announced on the Marseille IHU youtube channel they are soon to publish a study involving around 1000 cases (although I am not sure we can expect it to be properly randomized / blind). It’s a bit surreal here, our president Macron even visited the guy yesterday (we do not know the details of their discussions).
  • @nyanbinary1717
    Mid-March was absolutely and in all respects life-changing for me. I'm an educator, and my professional life imploded, followed shortly by my personal life when Washington state went into lockdown. I can only imagine what it was like for you as a physician. I hope you're doing as well as can be expected two months on.
  • @hephaestus9901
    As someone who takes both hydroqxycholorcquine and azithromycin for the past 13years,its scary to think that a little more than my usual dose could kill me in 30 minutes
  • @carebecousin
    I absolutely love how you explain everything to me! I'm a nurse and I've yet to hear anything clear and concise about these trials!!! Thank you! Keep up the awesome work!!
  • @SolidSiren
    I have a feeling that everyone else with science education knew, like I did, in January, that this was going to be very very bad and that it would definitely come here. What I didnt anticipate, as an American citizen, was that my federal government would ignore experts, and make policy decisions based on uninformed "gut feelings" when expert opinion was so clearly provided from so many sources. I knew in January to early February it was coming, what the growth rate appeared to be, and that we needed to do. If we had acted sooner, we may have saved hundreds of thousands of lives. But no one seems to care about anything but money. They refuse to do what is doable and would have saved so many.
  • @jaxder94
    "The virus has likely permanently warped the psyche of every human living in a society." This aged like fine wine.
  • @alaindumas1824
    Well said. I have been in medicine for 40 years and this article was by far the most ridiculous I ever read.
  • How can you be so pure hearted and not be a liar as most of the media. Truth... this Nation is hungry for truth tellers.
  • @lbaldwin51
    Thank you for this video. It’s very important that serious and honest works like yours are considered in times like this.
  • @telesniper2
    I was in a tropical country and felt somewhat ill one day. I used one of my unicorn tests and came up positive. I went to a doctor's office and told him I was going to travel to a friend's cabin in the jungle and I would like to get some Hydroxy chlo riqu ine as prophylaxis against malaria. After taking H CQ for a full day I felt completely fine the next day. Just my 2¢! Unlike other treatments, this actually was safe and effective!
  • @brianbanks3044
    how did i miss this 17 months ago....god, we needed to hear this then on EVERY news outlet