The Sad Truth About Serotonin | SSRIs, LSD & Depression

so sad i was prescribed this shit as a kid(15) for ocd and "depression" despite living in a toxic environment with abusive parent. sad how common this is. thanks for bringing this stuff out there anatomy of an epidemic is a great book on this subject

This channel keeps getting better. Thanks!!!

Damn your video quality has improved so much. I love the cinematic feeling you have. Good choice of music, quite eery so far (also like 8 mins in)

So glad I found this channel.

The metroid ambiance really hits for me! Great content my man the value is off the charts

Very refined and well done. I'm here before you (hopefully) blow up. You're spreading the good word.

Amazing cover and insight of SSRIs guys. Another reason I think some ppl have a perceived benefit from SSRIs is the placebo effect. For some, it makes them feel 'looked after' and this is enough comfort to make them feel better than without it initially. Unfortunately as time goes on more serotonin isn't going to benefit them.

Dude this channel is my favorite I found in a long long time 👍👍

💎Came here from Danny Roddy’s live.... GREAT video man. Looking forward to more of these 👌🏽

rewatching this and im so happy to see james corbet on this, thanks again for this video im going to show it to my bf and friend (my friend is considering ssris)

Becoming a huge fan since I found you

Thank you for making this video, king 👑

Knew about the MKUltra and lsd stuff, but not the stuff about the SSRIs...Nice job on the video

One of the things that creeps me out is not just the increase in suicidal thoughts but the ability to go through with it and a lack of care for others. My auntie was depressed, probably on a bunch of pills, and she hung herself near the front door from the second floor of the house. Her kids could have found her and I don't believe for one second she was the type of person to do that. It was like her ability to think about other people was stolen from her. Another example would be the Welsh town where so many young people hung themselfs. Or Sylvia Path... I'm sure she was given something that made her think sticking her head on the oven was actually a swell idea.

Pausing at 10 mins to say I was so hooked I fully forgot I was watching a video about Serotonin. Fantastic work. edit Good idea putting the BO theme music in the bg lol

16:10 - fat gain 16:25 - cortisol 17:00 - hibernation 17:50 - energy conserving 19:15 - brain 25:30 - Anhedonia 25:53 - rumination

Just found your channel. Loving it so far. The COD lobby music in this video is nostalgic af

A very interesting video. Thanks

I love this channel.

Medical student with a particular interest in neuroscience here, almost everything said in this video is either inaccurate, oversimplified or blatantly wrong. First of all LSD is not a “serotonin antagonist” it actually agonises all serotonin receptors - including indeed certain autoreceptors that decrease firing rate of serotonin neurons, however post-synaptic receptors are still being activated by the LSD molecule itself even if serotonin isnt being released. The psychedelic effects come from agonism at 5HT2A receptors, when LSD binds to them it activates a specific intracellular pathway that the endogenous agonist - serotonin - is unable to. To present LSD’s effects as a result of antagonism to serotonin which = thinking inside the box is beyond far fetched from what actually happens. Secondly you’re right that serotonin is not a happy chemical the same way dopamine for one is the brain’s reward centre but it’s been shown that abnormalities with serotonin neurotransmission - not necessarily a dysfunction - can trigger symptoms of mental illnesses.There are several different serotonin receptors - most G-protein coupled and others ion channel-dependent - and all of them have vastly different effects. For instance the 5HT2C limits dopamine transmission and also causes anxiety, dysphoria and appetite loss. Chronic treatment with SSRIs tends to downregulate this receptor’s expression in some cases thus possibly alleviating some of these symptoms. Post-synaptic 5HT1A receptors are involved in the release of oxytocin - the love hormone - as well as in reducing anxiety and irritability. 5HT2A receptors when activated by profound increases in serotonin such as seen in for instance MDMA users seem to elicit positive mood and sociability. Other serotonin receptors dont even affect mood and are just important for regulating other physiological responses like temperature, appetite and inflammation. The increased suicidality seen in Prozac is mostly related to the initial weeks of treatment when the brain responds to the drug by reducing serotonin transmission until the autoreceptors desentitize. There is also no evidence whatsoever that serotonin is in any way related to Parkinson’s Disease, a condition generally accepted to be caused by oxidative stress destroying dopamine neurons. Overall, the serotonin system is indeed very complex and poorly understood and I agree SSRIs shouldnt be given out to ppl, especially kids and teens, the way they are. But this video’s oversimplification is just as bad as that of the big pharma’s.