Uric Acid with Dr. Ben Bikman

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Published 2024-05-15
Timestamps:

02:10 - Overview of Uric Acid: Explanation of what uric acid is and its origins from purine metabolism.
03:16 - Uric Acid and Hyperuricemia: Discussion on uric acid production, excretion, and the condition of hyperuricemia.
05:09 - Gout and Uric Acid Crystallization: How high uric acid levels lead to gout and kidney stones.
07:08 - Importance of Uric Acid in Metabolism: Why uric acid is important, its clinical relevance, and its connection to insulin resistance.
09:14 - Uric Acid and Inflammation: How uric acid causes systemic inflammation and contributes to insulin resistance.
12:27 - Sources of Uric Acid, Purines and Fructose: Detailed breakdown of purine and fructose metabolism leading to uric acid production.
16:31 - Fructose Metabolism and Uric Acid: The role of the liver in metabolizing fructose and its link to uric acid production.
22:47 - Pharmacological and Nutritional Interventions: Treatments like allopurinol and the benefits of allulose in reducing uric acid.
30:34 - Ketogenic Diet and Uric Acid: The effects of the ketogenic diet on uric acid levels and insulin sensitivity.

Summary:

In this episode of The Metabolic Classroom, Professor Bikman explores the significance of uric acid, particularly its impact on insulin resistance, a critical metabolic marker.

He begins by defining uric acid as a byproduct of purine metabolism, which usually gets expelled through the kidneys into the urine. However, when uric acid production exceeds its excretion, it accumulates in the blood, leading to hyperuricemia. This condition can cause uric acid to crystallize, often in joints, resulting in gout. Uric acid can also form kidney stones and contribute to inflammation, which is connected to insulin resistance.

Dr. Bikman delves into the biochemistry of purines and their breakdown into uric acid. He emphasizes that the excessive accumulation of uric acid in the blood is detrimental, as it activates inflammation pathways such as the NLRP3 inflammasome. This systemic inflammation triggers the production of ceramides, lipids that directly antagonize insulin signaling, causing insulin resistance. The prevalence of insulin resistance is a growing health concern, linked to chronic diseases and exacerbated by high uric acid levels.

A significant portion of the lecture is dedicated to the relationship between fructose consumption and uric acid production. Ben explains that the liver metabolizes fructose into uric acid through a series of biochemical steps, bypassing regulatory mechanisms that usually limit glucose metabolism. This unregulated fructose metabolism leads to a high production of uric acid, contributing to its accumulation in the blood. The increase in fructose consumption, rather than purine-rich foods like red meat and seafood, is implicated in the rising rates of gout and uric acid-related metabolic issues.

In addressing solutions, Dr. Bikman highlights pharmacological interventions like allopurinol, which reduces uric acid levels and improves metabolic health, albeit with potential side effects. He also discusses allulose, a rare sugar that shows promise in lowering uric acid and improving metabolic outcomes. Preliminary research suggests that allulose can reduce uric acid levels by enhancing its excretion through urine.

Additionally, Ben touches on the ketogenic diet, noting that despite potentially increasing uric acid levels, it effectively reduces inflammation and improves insulin sensitivity due to the anti-inflammatory effects of ketones.

Dr. Bikman concludes by stressing the importance of understanding uric acid’s role in metabolic health and its connection to insulin resistance. He encourages further research and practical dietary interventions to manage uric acid levels effectively. By integrating pharmacological, nutritional, and lifestyle approaches, individuals can potentially mitigate the adverse effects of high uric acid and improve overall metabolic health.

#MetabolicHealth #UricAcid #InsulinResistance #Nutrition #Metabolism #Health #Wellness #HealthyLiving #Gout #KidneyHealth #Inflammation #Diabetes #Fitness #WeightLoss #Diet #Allulose #Fructose #CellBiology #KetogenicDiet #HealthyLifestyle

Studies referenced in this episode:

pubmed.ncbi.nlm.nih.gov/24769205/

www.sciencedirect.com/science/article/abs/pii/S193…

www.metabolismjournal.com/article/S0026-0495(65)80…

Learn more at: www.insuliniq.com/

All Comments (21)
  • @jamesgordon8867
    Why don't we have more professors like this gifted educator?
  • @jamesgordon8867
    Dr. Bikman, If this is how you talk to your kids, they are truly blessed! Your heart comes out when you talk! Thank you, sir, for teaching outside the classroom! We need your lectures!
  • @thomasarcher4034
    Thank you for not focusing on gout. I've had gout. Although painful I doubt many people have died from it. In reality, gout is a blessing in that it should alert you to hyperuricemia and the possibility of uric acid crystals elsewhere. We may become aware of gout with a joint hurting but uric acid crystals have been found many places-- in coronary arteries, aorta, heart valves, myocardium, kidneys, prostate, and pancreas amongst others. Crystals have even been found in atherosclerotic plaques. Its frequency is VERY underappreciated because it's hard to detect. Routine tissue fixation with formalin washes out uric acid crystals. Likewise, tissue is usually cut 7 microns thick for microscopy. Uric acid crystals are usually linear and, if they're perpendicular to the slide, will appear as a small dot. To see uric acid crystals one has to preserve the tissue with methanol, not formalin. Following this, special lighting is required to see the crystals. Studies which have employed this method have shown crystals to be far more extensive than the joints. I can't imagine that uric acid crystals in the coronary arteries initiating an inflammasome reaction is good. Uric acid crystals don't show well on routine x-rays and scans. It usually requires a specialized cat scan called dual energy CT (DECT scan). These scans will often show uric acid crystals in the calcium in atherosclerotic plaques. Unfortunately gout is treated poorly. Give an anti-inflammatory and if it recurs we'll "think about" treatment with allopurinol or febuxostat. Hyperuricemia, not JUST uric acid crystals, IS serious. It's like a criminal whose fingerprints are left behind at many crime scenes- the heart, kidneys, liver, pancreas. The tragedy is that we have good drugs and it's usually easy to treat. Anyone diagnosed with gout or hyperuricemia should be thoroughly evaluated for heart, liver, and kidney disease. For every molecule or uric acid produced there is also a molecule of hydrogen peroxide generated. I've often wondered how much pathology is caused by this, as opposed to the uric acid itself.
  • @nannygranny9534
    Thank you so much for your videos. I have developed fatted liver, Hasimotos, kidney stones and type 2 diabetes. The only one I was told about was the kidney stones when I went to the ER. Fatter liver I learned about when I got a copy of the report. Never once has any doctor told me about any if the issues. The diabetes I found by buying a glucose blood meter. You have given me a path to regain my health. God bless you!!!
  • The more I listen to these lectures, the easier they are to understand.
  • @FrannyBeepsAttic
    Professor Bikman, you are so gifted with your explanations, thank you so much for sharing!
  • @krabbend8
    I eliminated gout completely by skipping all fructose (fruit & sugar)
  • @hiraijo1582
    I am a retired MD and really appreciate your lessons and what I learn. I am not so sure about allulose though. Side effect bloating always tells me that something messes up your gut microbiome. I prefere reducing sweets to an occasional treat which gets easy the longer you are on a rather low carb diet.
  • Thank you Dr Bikman, as always it is a pleasure to be in your classroom. I have someone in my life with gout and they significantly decreased fruit and fruit juice and he is eating more meat, and has not had another gout attack after making those changes.
  • @WisdomStreetAU
    Not all gout is caused by uric acid. Unless the joint fluid is tested, it is just assumed its the uric acid. For those on carnivore etc, if you have gout, it could be oxalate crystals. Stored up oxalates (from when plants were eaten) get released from the body in cycles (can take years). If the load is too much to excrete at once, the oxalates get 'dumped' around the body waiting for excretion, causing many different symptoms. Its common for the oxalate crystals to be found in joints, and big toe gout. Feels the same as uric acid crystals... Most doctors assume big toe pain and swelling is uric acid crystals but there are other causes for the same symptoms. Sally Norton is the expert for oxalates. She explains how to slow down the 'dumping' and manage the symptoms.
  • @jeff_rowe
    Thank you Professor Ben Bikman. I have enjoyed your social media posts over the last three years. Disciplined carnivore for 4 years, Uric Acid 11.7 - 13.2 mg/dL over those three years. This could be life changing for me. More to come.
  • @PTL77
    What a great teacher! Thank you Dr. Bikman, the podcast host, the sponsor and the insightful viewers. May our quality of life improve everyday.❤
  • @Donna-iu4lq
    Thank you so much for your explanations. I was with you until AMP came into the picture, then I sort of glazed over, but please don't stop giving us the details! I just need to go back and listen again. The college age kids may get it in one try, but at 72, I'm still passionate about learning and improving my health, but need to hear it more than once :) So appreciative for your videos and your gentle style that brings a complicated subject down to our level. You, Sir, are a gift.
  • As someone who loved chemistry and got through qualitative analysis in college, I love listening to you. as someone who has used the ketogenic diet to go from 180 pounds and 60 units of insulin to 120 pounds and no medicine I am thrilled to listen to you. Thank you.
  • It still amazes me that we know so much about cells and their specific jobs .but what's even more amazing is the ability of this ADr. to explain it in layman terms! Thanks a lot from a true fan
  • @jamesgordon8867
    "Why we get sick " should be in every doctor's office: waiting room & exam room
  • @carlloeber
    I tell you this man is making BYU look really good on YouTube science lectures ..
  • @helenl7967
    I feel like I am back in my 2 favorite nursing school classes, Anatomy & Physiology and Endocrinology, with a big twist, up-to-date research and knowledge about what is making us sicker. Thank you Dr Bickman. I am eager to inform my hubby so he/we can implement some changes that may work. He suffers regularly from gout attacks and takes a toxic medication since that is the only thing that alleviates his pain and allows a modicum of relief and mobility. 🎉🎉🎉
  • @yvonnekiwior9633
    Morning coffee with Ben!!!! My favorite teacher ever🎉 Great topics always❤