Exogenous Ketones with Dr. Ben Bikman

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Published 2024-05-23
In this episode of The Metabolic Classroom, Dr. Bikman explores the history, science, and benefits of ketones, focusing on exogenous ketones.

He begins by explaining the fundamental chemistry of ketones, emphasizing the difference between endogenous (produced within the body) and exogenous (introduced from outside the body) ketones. The three main ketones discussed are acetoacetate, which can convert to either acetone (excreted from the body) or beta-hydroxybutyrate (BHB), the primary ketone measured in metabolic assessments. Ketosis, the state of elevated ketone production, is typically inhibited by high insulin levels, which direct metabolic processes away from ketogenesis towards lipogenesis (fat creation).

Ben highlights the significant benefits of ketones for brain health. He disputes the common belief that glucose is the brain’s preferred fuel, citing research by Dr. George Cahill that indicates the brain relies heavily on ketones during fasting. Ketones have been shown to improve cognitive function, reduce oxidative stress, and alleviate symptoms of neurological disorders like Alzheimer’s and epilepsy. Beyond brain health, ketones enhance physical performance by increasing ATP production efficiency in muscle cells and boosting metabolic rates in fat tissues, thus promoting fat loss.

The classroom also addresses the evolution and advantages of exogenous ketones. Early forms of exogenous ketones, like ketone salts, had limitations such as mineral imbalance and poor taste. Advances led to the development of ketone esters and bioidentical BHB, which are more effective and palatable. Exogenous ketones can help control appetite, reduce inflammation, and improve exercise performance. Despite initial concerns about their potential to be converted back into fat, Professor Bikman clarifies that this is not a risk, as the liver cannot reverse ketone production into fat.

Overall, Dr. Bikman emphasizes that while ketones themselves offer numerous metabolic benefits, the primary advantage of a ketogenic state is maintaining low insulin levels, which supports fat burning and overall metabolic health. He encourages the use of exogenous ketones to enhance these benefits, particularly for managing cravings, improving physical performance, and supporting cognitive function.

00:01 - Introduction to Ketones
01:58 - Types of Ketones - Explanation of the three main types of ketones: acetoacetate, acetone, and beta-hydroxybutyrate.
02:58 - Ketones and Blood Acidity - Discussion on how ketones can affect blood acidity and the distinction between ketosis and ketoacidosis.
04:04 - Insulin's Role in Ketone Production - How insulin levels determine whether the body produces fat or ketones from acetyl-CoA.
07:23 - Benefits of Low Insulin Levels - Overview of the metabolic benefits of low insulin levels, including improved fat burning and metabolic health.
08:19 - Ketones and Brain Health - The positive effects of ketones on brain function and cognitive health, debunking the myth that glucose is the brain's preferred fuel.
13:33 - Ketones and Physical Performance - Evidence that ketones improve physical performance and energy efficiency in muscle cells.
17:31 - Anti-inflammatory Effects of Ketones - Ketones’ role in inhibiting inflammation and their benefits for inflammatory disorders.

#Ketones #Ketosis #ExogenousKetones #MetabolicHealth #InsulinResistance #BrainHealth #CognitiveFunction #WeightLoss #FatBurning #KetogenicDiet #LowCarb #Inflammation #Type2Diabetes #PhysicalPerformance #benbikman

Studies Referenced:

Alzheimer’s and Parkinson’s (Cunnane et al., 2016): alzres.biomedcentral.com/articles/10.1186/s13195-0…

Ketones Elicit Distinct Alterations in Adipose Mitochondrial Bioenergetics: pubmed.ncbi.nlm.nih.gov/32872407/

Ketogenic Diet Reduces Midlife Mortality and Improves Memory in Aging Mice: pubmed.ncbi.nlm.nih.gov/28877458/

The Effects of Ketogenic Diet on Insulin Sensitivity and Weight Loss, Which Came First: The Chicken or the Egg?: pubmed.ncbi.nlm.nih.gov/37513538/

Learn more: www.insuliniq.com/

All Comments (21)
  • As a construction worker, I learn something from every one of your videos. I just wish your field of science and your knowledge of it would be a textbook that all doctors would have to learn from before they can practice medicine.
  • @carlor.s.4742
    Dr. Bickman, I can't tell you how much I love these lectures! In fact I'm developing an addiction to them-LOL! I'm a retired clinical psychologist & have always had an insatiable thirst for knowledge. I spend my evenings watching lectures like these instead of watching bad movies. Although I've watched many interviews involving yourself, I didn't discover this channel until recently. Thank you so much for allowing me to go back to school & learn--the thing I most like to do!
  • @jobrown8146
    This "student" is learning more from these lectures. Thank you very much.
  • @rothelsbeth
    I've been using exogenous ketones! I've been following the Keto diet for 2.5 years and then switched to carnivore for the last 18 months. Dealing with advanced Osteoarthritis, I've found that ketones act as my pain reliever (better than painkillers). I've been keeping track of my ketone levels... Here's the interesting part - if my ketosis level drops below 1.5, I experience pain. However, after consuming ketones, an hour later the pain disappears and my levels are between 2.3 to 2.8. My GKI stays between 2.8 to 3.3 every day. It's truly remarkable! Thank you for all your fantastic videos.
  • @caitlin6151
    I started using exogenous ketones after hearing you talk about using them. I have one client that I visit every week for 6 hours and her house is made of candy. I drink the ketones and go through the whole visit without a horrible urge to eat the candy. I am so thankful I started listening to you.
  • @2makeshiftwings
    The more I listen to you the more I am so thankful I listen to you.
  • @googoo7750
    I'm so glad people like you have the energy and patience to fight the flow of literal crap oozing from the media. Thank you!
  • @gt27312
    I'm an elderly woman who's been keto for 4 years. I follow that protocol to reduce inflammation and weight, but also because of the dementia that runs in my family. I do my best to keep my cognition high so I have recently started to take exogenous ketones because I heard it was valuable for brain function and health. Whether it is a placebo effect or actual improvement, I experience increased clarity and awareness when I take exogenous ketones before a "study" session. I have not experience much difference in weight control but I do feel some improvement with inflammation. Thank you for sharing your knowledge and experience with us in a way that even laymen can understand!
  • @englander2626
    Thankyou for the excellent video. There are a lot of recommendations to take coconut oil and MCT oil. But it's unclear to what degree these oils are converted to keytones for people who have elevated insulin levels. If you could do a companion video to this one to clarify MCT oil and keytones that would help a lot.
  • I’m on 9 years 0 carb lost 55 pounds but belly fat never gone. Very high protein low fat. Now last 5 month I eat very high fat like 200-300 grams fat 60-90 grams protein I gained muscle and lost belly fat . My glucose under 80 ketone all ways 2.5 to 3.9 . To much energy. Day time only eat ghee with coffee night eggs yolk small steak some bacon add more butter.
  • Damn, you hit it out of the park with this class. You filled in some of the holes I have been curious about. It is a privilege to attend the metabolic classroom.
  • @gonefishing7813
    I work for our State Court system I’m on call 24 hr…if I’m called out during the night, which is very normal, sometimes when my sleep is interrupted early in the night usually around midnight I wake quite “addled “. I take a ketone “shot” as soon as I get up by the time I arrive at the scene of my call out, I find my head clear fully prepared to deal with the load of detailed paperwork required
  • @CarnivoreScott
    Thank you Professor Bikman! I really appreciate your dedication to bring knowledge to the masses. I know your content is forever pushing the boundary of my ignorance back, it seems a never ending task. So again thank you for all you, and your team are doing. More informed patients is how the medical establishment will come to know these things you are teaching. I feel for Dr's and medical professionals as they are in a very tightly controlled line of business. It isn't only the customers (patients) they are trying to keep alive and or well, but the hospital administrators, investors, Big Pharma, Insurance, and of course the legal community. With so many pressures and so much at risk I can see how one would be required to stand on the platform of "Standard of Care." It's sad, but like my ignorance none the less true. All this to say thank you for helping us in the battle to secure better health.
  • @KirstiCheetahh
    Hi doc! I love your lessons! I have been eating keto/carnivore/cheesovore for 2 1/2 years to get rid of tendon pains, burning pain in my feet, fatty diarrhea. Great results! Woman, 54, LMHR, BMI 18.5 , play tennis fasted, retired, no stress. One problem persists: insomnia since early childhood, very active brain. It takes at least 2 hours to fall asleep and after a few hours of sleep I wake up and can not get back to sleep. I think I get low glycemia and high cortisol in the middle of the night. My liver seems slow in making glucose and ketones. Yesterday I took a teaspoon of MCT oil (70% C8 / 30% C10) in my yogurt at 8 pm (2 hours before bed). I have slept the whole night without waking up 😃 I hope this will continue.
  • very cool! basic carnivore here...I am never hungry, have absolutely no cravings....I find your detailed explanations really helpful.Thanks for everything you do!!
  • Whenever I get deep into ketosis via low-carb eating, I get this brain surge of focusing on the tasks at hand and the tasks on the back burners. I will clean out reorganize, improving our home centers, closets, sewing rooms, and many other cluttered places. I love it!! ❤️ 🏡 😊
  • @karene9446
    Dr. Bikman, I use them to get back to sleep. Insomnia's been a problem for decades now - especially when I'm in ketosis and for some reason, I can get back to sleep if I drink a gulp (I use HVMN's ketones.) They are also a tremendous help in reversing the grogginess and brain fog from lack of sleep. It seems counterintuitive if I'm already in ketosis, but I wonder if my body needs the energy to rest well. I notice a difference pre-exercise, but the sleep assistance is the most powerful. Oh, I should also add that they're just as effective if I've eaten enough carbs to take me out of ketosis.
  • Hi Dr Bikman, I used exogenous ketones when I had covid recently (first time of having the virus). I took 1 bottle of KetoneIQ ketone ester per day, over 3 days, in the morning with decaf coffee and sine Mct oil and noticed a calming effect and less brain fog than when i first awoke. I was already on carnivore diet. My flu-lime symptoms were of shorter duration (2 days) than my husband, who got it (4 days), who wasn't on a very low carb diet and was not using exogenous ketones.
  • @robinq5511
    Ketone-IQ Pre-Workout: I take the 35 mL dose 30 mins before my 1 hr workout with a trainer. They boost my energy, mood and suppress my appetite for 2 to 4 hours. I usually take them fasted or after my decaf coffee with MCT oil depending on when I am going to the gym. I am a 74 yr female who is recovering from prediabetes & insulin resistance - thanks to you and a low carb diet! They do literally taste like cr@p but I keep mine chilled and down 8 oz of water immediately after. I have not experienced any negative side effects. They cost the same as the bioidentical ones you suggested but you get more servings. I test my ketones after my workout and they range anywhere from .5 to 1.5 probably due to the intensity of my w/o and how long I have waited to test. I also seem to have better recovery when I take them - less stiffness and soreness.
  • Be thrilled! I continue to learn something new from you almost everytime i listen to your lectures. I keep coming back for more.