Uric Acid: A KEY Cause of Weight Gain, Diabetes, Heart Disease & Dementia | Dr. David Perlmutter

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Published 2022-05-06
Levels Chief Medical Officer, Dr. Casey Means, chatted with our advisor, Dr. David Perlmutter on the discovery of how the elevation of uric acid in the body is a causative mechanism in the development of metabolic diseases, and one of the key links between obesity, diabetes, heart disease, neurologic diseases like dementia, ADHD, fatty liver disease, and more.

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They also covered:
- The several mechanisms of how uric acid causes cellular dysfunction and insulin resistance, including oxidative stress, inflammation, and even preventing insulin from getting out of the blood stream effectively.
- The evolutionary reasons why the metabolic dysfunction and weight gain caused by uric acid would have benefitted us historically in terms of low access to food and water, by letting us more easily pack on weight and raise blood pressure. And how we now live in an evolutionary-environmental mismatch where this survival mechanism is now hurting us in the face of caloric abundance.
- The different dietary and environmental factors that generate uric acid, including fructose, purine rich foods and umami foods, dehydration, alcohol, and more.
- The optimal levels for uric acid.
- How uric acid impairs our hunger signals, drives us to eat, and even promotes risk taking behavior. We talked about how to reverse high uric acid levels as a way to unlock optimal health.

00:00 - Intro
03:12 - More than just gout
05:06 - A causative role
07:44 - The number one cause of death
15:24 - Evolutionary environmental mismatch
16:58 - High fructose corn syrup
22:27 - The dangers of uric acid
23:38 - Uric acid and dementia
30:33 - Too much fructose
41:32 - Erectile dysfunction and cardiovascular risk
01:03:17 - No need to eat sugar

Transcript & Show notes: www.levels.com/podcasts/116-uric-acid-a-key-cause-…

All Comments (21)
  • @tonyprice2256
    I am 66 and use no pharmaceutical products - prescribed or over the counter for any reason whatsoever. I used to be morbidly obese according to two medical doctors. I used to have a fatty liver condition. I used to have pre-diabetic symptoms. I used to have edema - swelling in the feet and lower legs from excess fluids. That edema sometimes caused serious infections called cellulitis that would require hospital stays and intravenous antibiotics. I used to have COPD symptoms from decades of smoking. I used to have occasional high blood pressure and other chronic health problems for decades. All of these are gone. And they are gone because of intermittent fasting and eating high quality locally produced real foods. For just over two years, i have been eating just one good meal every day that i prepare myself. I avoid sugars, all highly processed junk 'foods' and excessive carbs - no breads, cereals, pastas, etc. I am healthier and stronger than i was 10 years ago. It is almost like aging in reverse! Barring any serious injuries, there is no need to see any medical doctors. I have no plans to see any in the foreseeable future.
  • @shancan6328
    My grandmother walked everywhere she went, ate mostly out of her garden which took up the better part of her back yard and worked in that garden often. I remember her taking the peels and veggie scraps out with a shovel and burying it in the garden. She drank milk, ate butter, made homemade bread every week, baked cookies and cakes and would eat the fat off of the roast along with mashed potatoes and gravy. Breakfast was eggs and bacon when or oatmeal. She had "juice glasses" that would maybe hold a half a cup of juice that she would squeeze from oranges. She had sauce dishes that held homemade apple sauce and other fruit sauces. Meat and milk and dairy were from local sources. She died one month before turning 104.
  • My oldest son is in his early 20's and he has type 1 diabetes. But thank God for this piece of article youtube.com/post/UgkxVYhghKWmrUgXARZ_ydZTvmmcrw5L0… At first he thought he had the flu and was lying down on the bed for three days until his sister took him to the hospital. They took his blood and it was 600. What I do not understand is how he could have gotten it, since no one in the family has it. But he is winning the battle now. This is good stuff
  • I’m a physician and have been saying this for years. Wish more would think independently, analytically and strategically and not just from a memorization perspective. Appreciate this video. More docs need to listen and learn the truth.
  • @ChunkySalsa75
    There was a British doctor in the early 70s that said sugar was bad and he was laughed out of his field - the medical profession owes dr yudkin a huge apology, and needs to be recognized for his brilliant work
  • @Cocora22
    My doctor recently told me that the tests I was asking for, during my annual physical, were not necessary because I don't have symptoms. I'm 70 and generally very healthy. I told him that I had been to the endocrinologist a couple of years back and he told me to watch my TSH levels. They came back very hi. I begged the doctor for some of the tests that Dr. Berry and his colleague recommend as part of a health screening and he said no. No Uric acid test recommended. So none done. I just can't wrap my head around how these doctors practice medicine. My experience has totally been that they don't want to find out what's wrong they just want to cram a pill down your throat and damn you if you challenge or question their approach!
  • After the Covid debacle and how the health authorities all around the world couldn’t even discuss how to boost immunity naturally, I understood why they don’t tackle diet issues and education. The entire health system is geared towards caring for sick people, through “medicines” to nursing the acutely sick
  • @modalities
    Anecdotally, I suffered from chronic gout (Uric Acid levels) as a function of how much fructose (HFCS) i was consuming and creating metabolic dysfunction, for nearly 8 years. I would have about 2 flares each month. I started a carnivore diet in January this year and had the Uric Acid levels measured each month (decreasing from 9.2 to 5.9) by June (this year). No HFCS, Sugar or substitutes or alcohol. In March (going back in time a bit) I stopped taking Allopurinol. I had also lost 42 lbs by May. Two weeks ago I wanted to test my response to HFCS and consumed 13 grams (intentionally). I had (and still recovering from) a gout flare within 10 days of consuming the 13g of HFCS. After 7 months I was shocked and thankful that I had Colchicine and Allopurinol. So it appears that I have more work to to on my metabolic health. Thank you for publishing this video and the contribution of Dr. Perlmutter.
  • @CP-nf9my
    When we took sugar out of our diets 25 years ago because we saw it affected our children's behavior, we were viewed as mean, even abusive parents. Thank God for mean (and informed) parents.
  • @TaipanTex
    OMG! I'm a medical professional and just hearing all this just blew my mind! To say understanding how uric acid affects these multiple pathways in the body is starting to tie up a lot of loose ends regarding the pathogenesis of these diseases is an understatement. It's huge! You guys are like the "Jedi Knights" of the medical world! Thank you for your dedication to learning how these complex pathways work.
  • @dashagudym3938
    I love this channel. As someone who studied biochemistry I really appreciate how much you guys go into detail. Excellent!
  • My father is an Internist with borderline high uric acid levels. He eats a lot of sweet fruits like grapes and moderate amounts of animal protein. I am a radiologist and I rarely eat fruits or anything sweet! I have borderline/high uric acid levels too. We were both educated in the classic, simplistic medicine paradigm, so we thought this uric acid thing has to do with genetics. I forgot to mention I drink very little water and eat lots of salt! What we just heard makes biochemical sense and we will try it. Medicine is fascinating when you start connecting the dots. Thank you
  • @chasleask8533
    I cured my gout overnight by cutting out all sugar . The disinterest shown by my doctor is almost comedic . Beware , sugar , yeast , alcohol .
  • @digmatology
    I've been telling people sugar is the problem and not fat for 12 years and people called me stupid. It's nice to see science and doctors finally seeing and talking about it, it's sort of a vindication. Everyone needs to be taught this and to understand that children needed to be protected from sugar as it is highly addictive and unlike heroin its on every grocery store shelf. There is no such thing as an essential sugar......
  • @trioray9090
    Don't think you are boring Dr.P, I am not a pharmacist, but I read the whole Merck Manual myself.
  • I’m in so much pain with fibromyalgia, I find when I eat sugar it kicks my pain in, I broke out and ate sugar yesterday , plus I ate GF pasta, as I’m celiac , today I can hardly get out of bed. I’ve finally worked out 🤷🏼‍♀️ sugar is poison to me. When I eliminate sugar my pain decreases. Thank you both, I love this video, it’s packed with information that makes so much sense.
  • @ziggy33399
    This was a superb video (for me). I’ve been obese for years. I was slender all my life & when I began to feel the shift , told my family physician I thought my metabolism had changed. She said the metabolism doesn’t chance. I’ve taken ALL the shame & blame as I blew up. Now I’m 73 yrs old, a former dancer shame makes me unwilling (and unable) to walk or even stand without pain. I swim to get things moving . But I absolutely crave carbs. I drink smoothies (organic fruit). I’ve been told I just let myself go. I’m a shame. I have to “face this “, etc. I can assure yo shame or being yelled at daily has not worked. I DID, however, buy a glucose monitor when I became interested in intermittent fasting. Recently I found the two medicines I WAS ON caused weight gain (1) and the inability to lose (2) weight. So again, what I assumed was my weak character flaws & failures while water fasting were perhaps exacerbated by simply not understanding. Namely, the role of sugars as presented here. Get that monitor and starting over. Wish me luck. Need both books (gave his grain brain book to a neighbor who was diagnosed with Alzheimer’s ). Thank you for your guest today. Thank God for recommending I watch it.
  • I'm a physician and most of this is new to me. I can't thank you enough for putting together this research and connecting the dots within the metabolic syndrome. I checked my own labs and there has been no uric acid level checked by my provider in over a decade. Thank you again. Great work!
  • Dr. Pearlmutter should be awarded the Metal of Freedom for all of his contributions to the microbiome and, thus, our good health.
  • @kayoxford7442
    Listening to for the second time. I'm an admin. of a diabetic group...never knew this! Explains so much! Sharing with my group! Thank you so much!