Exciting Developments in the Treatment of Peripheral Neuropathy | Dr. Fernyhough & Dr. Calcutt

Thanks so much for having these fine gentleman on. They’ve been quietly working on this for many years and they need some exposure to secure their next funding.

I think I will stick to natural methods of improving mitochondrial function. (My partner and I both have peripheral neuropathy since getting covid..neither is diabetic). Fasting exercise lower carb diet acv sunshine heat and cold therapy lymph drainage omega 3 rich small fish. Supplementation such as turmeric magnesium NAC ALA etc. In my experience side effects seem to usually outweigh the benefits of prescription drugs. Interesting talk though. Thank you all.

If I get windfall will send chunk of change your way! Thanks Dr P for not interrupting the guests w/ constant requests for further explanation for lay persons. We have google and makes interview flow

My oncologist had me ice my hands and feet during chemo infusion. It was uncomfortable, but I did sooo much better than anyone I know who had same chemo. I do have some neuropathy but very little comparatively. I was so grateful!

Blood flow, nitric oxide, increasing VO2 Max seems like all would help, beyond the blood sugar issues.

Peripheral neuropathy, is often experienced in patients with autoimmune illnesses, - Sjogrens, Mast Cell activation, autoimmune dysautonomia POTS, Lyme disease.

You gentlemen are doing great, inquisitive work. I am hearing several clear examples of the FDA steering what they care about..... symptom treatment with pain drugs and away from root cause analysis altogether. They do this by only asking or allowing certain questions to be asked and explored. I think it is obvious that non-pharma medicine is simply not allowed a seat at the table.

I have Type 2 diabetes. And had two severe bouts of neuropathy on my left leg and feet. So severe that the pain caused me to stop walking and I had to take painkillers to be able to sleep. I was taking Rosuvastatin drug or other statin drugs on and off for about four years. So, I heard that statin drugs can cause or make worse neuropathy. So, I stopped taking the Rosuvastatin pill and the agonizing neuropathy pain on my left leg subsided after about 13 days. And I was able to walk unhindered by pain. Although, I still have residual numbness on my left foot and a tiny amount of numbness on my right foot. Now, I am able to go for long walks and climb stairs at the park which has 85 steps.

Fascinating discussion. The takeaway for me is....stay healthy, look after your diet and avoid diabetes ect. as one illness leads to another.

Loved the talk, very scientific but understandable. I do not have diabetes, but a recent diagnosis of PAD. A little more about what causes foot pain in the absence of diabetes would have been helpful. I do have autoimmune thyroid and a build up of heat in my back L4-L5 which might be flaring up the neuropathy in feet? It's all a science project. Thank you

My sister has idiopathic neuropathy. She was told by her doctor that it was caused by her taking vitamin b6 over many years. So far after getting off the B6, she is not getting better. She also has essential tremor, but tested for adrenal tumors, none found. She is 79 and lives in Assisted Living, and her pain and imbalance makes her reliant on a walker. She doesn't have type two diabetes.

I looked up the negative side affects of muscarinic antagonists and they seem concerning, particularly in the elderly.

Covid left me with neuropathy in my hand. I still can't believe it's not discussed more! Soooo many people like myself. I hold onto hope for healing, but it's been 4 years. We need more funding and research, and we desperately need something to come out in the next five years or so. I really hope they are able to push something through.

My neuropathy is caused by spinal stenosis at L4/L5. My diabetes is considered under control / normal at an A1C of 5.6 and achieving this has not affected my neuropathy - it is still the same with dropfoot. The neuropathy started after a very serious bout of pneumonia and coughing which aggravated my stenosis that my doc did not take seriously and that caused a month in the hospital. Uric Acid is 391 umol/L.

My daughter & I have Charcot-Marie-Tooth (CMT2) a poly perpherial neuropathy.

Really interesting. I wonder if this drug could work for shingles or traumatic injury to nerves from say a car accident.

Ask the public for funding, GoFundMe or anything similar. The world will donate like never before.

While diabetic, I never had issues of leg neuropathy until I had an adverse reaction to Leviquin in 2016. My reaction was bad enough that despite walking 4 miles per day prior, within two days, I had to crawl down our stairs. The leg cramps that I never had before were intense and still plague me to some extent, even with taking 600mg of magnesium malate. Still have tingling on occasion, often leg cramps during the night. If you don't want to get medical help, tell a doctor that you had a reaction to Leviquin.

Re diabetic neuropathy: if tight glycaemic control is put into place early, neuropathy shouldn't occur. And, with normoglycaemia, neuropathy is reversible. And access to things like insulin pumps is a nonsense. I have had type one diabetes for 59 years, and have no complications. My HbA1c is 4.5%.

Interesting, so Pirenzepine could be delivered to the bladder via catheter to improve bladder control? OK, where do I get Pirenzepine Cream? Found it interesting the discussion on Mitochondrial Damage in nerves, would be interesting to see a NAC study wrt nerve function.