LDL size and Heart Disease (small dense vs large "fluffy") | Dr. William Cromwell

Incredibly clear communication by him without oversimplifying. You may have competition...

Dr Cromwell is amazing at breaking down this complex topic! I'm not a clinician nor a statistician but even I could follow his nuanced explanation.

So many people are still attached to the belief that you don't have to be concerned with LDL as long as they are large particles. It's definitely gonna take some time to change this common misconception.

I am super early! Love from an other (soon to be) dietitian from Greece! Keep up the great work mate for both the public and us scientists all around the world!

Great video! Many thanks for this Dr Carvalho

One of the best clear and concise summaries of particle size, particle number, and interactions as it relates to CVD risk. Thanks.

Thank you for the amazing content Gil! The part about FH is really interesting too.

7:32 over 90% of ApoB particles are LDL [however in a previous video, the same expert said that in most people LDL-C doesn't track well with ApoB, unless your LDL-C is very high or very low, so i'm left a little confused as to which one i should test, also considering that idk the ideal ApoB ranges.]. 7:41 here are the more atherogenic ApoB particles (the bigger ones are less atherogenic). 11:08 small and large LDL particles are equally atherogenic [this seems to contradict what i wrote in the line above]. 11:20 the LDL in familial hypercholesterolemia is large [and not oxLDL, i might add], yet the people with such condition have early events and cardiovascular disease. 11:59 we used to think that small was worse than large. 12:31 large and small are equally associated with heart attack, stroke, and events.

Thank you for covering this important and misunderstood topic, Gil.

Thanks for explaining this topic.

Excellent video! This was very interesting.

Thank you for covering this topic in great detail 😊

Thanks for a great video!

Great video Gil, thanks

Best nutrition channel in the world

Covering every excuse from their book! Good job!

Good info, Doc and Doc

A clear concise explanation of a very complex topic. Reinforces the importance of lowering Ldl and Apo B.

This is a video everybody eating low carb/keto/carnivore needs to see. Influencers in that area only showing people half of the information, despite it is nothing incredibly new, comming to dangerous conclusions. There has been boycotting of statins, mistrust in primary care providers and their advice, self interpretation of blood test results if you look at the comments of such videos. Difficult to see, yet ineffective discussing with those people. Half truths are extremly dangerous. Thank you for this video, an honour to hear from such an expert that my understanding of the topic is not wrong. I have a question though that has not been answered in this interview. In what cases does the determination of particle size sense in order to not overlook elevated risk, when you have somebody witout risk factors? As Dr. Cromwell was explaining the idea to look at particle size was given by the fact that there are individuals without otherwise detectible risk factors having myocardial infarctions. Family history would come to my mind. In diabetics and insulin resistance you would have elevated TG, so that would give a hint at small particle size, thus not needing advanced lipid testing? Or am I wrong in that regard?

That was very good, thank you. Although baffling not even a mention of Lp(a), even when discussing the most concerning ApoB containing particles. Lp(a) certainly should have been included.