I Was WRONG About Artificial Sweeteners? | Educational Video | Biolayne

As a PhD scientist who makes a living doing medical research, and has more than a passing interest in this subject because I am a type 2 diabetic, and I have worn a CGM, I think this study established nothing more than that by changing ones diet, you alter the gut microbiome. Layne is dead on that this is hard to interpret. It could be good, it could be bad, it could be neutral. There is no data in the study that supports am overall negative effect of NNS, and the authors even caution in the manuscript that based on this data one should NOT abandon NNS for sugar. Water will always be the best beverage, but I think for 100% of humans, drinking beverages sweetened with NNS’ is far better than drinking something sweetened with sugar. Having published in Cell myself, I agree with Layne that as high a profile journal as it is, there is plenty of great research and plenty of crap in the journal as well. This study is well designed on the whole, but its publication in Cell will cause its impact to be far greater than the dataset presented justify, in my opinion. Finally - an anecdotal finding with an N of 1; my pretty healthy 80 year old Mother drank TAB for decades and still uses Sweet-N-low in her multiple cups of coffee everyday. So if you are one of those people who insists that NNS’ are bad, you will likely cite this study, probably incorrectly, as supporting your point of view. If you think NNS is good, this paper does little to change your mind.

I love how Layne just sticks to the data, regardless of whether it matches his expectation bias and delivers the content with no bullshit. If only the media would report on scientific studies this way.

This is the longest "I don't know" response I've ever witnessed

As a sports medicine physician, I LOVE these deep dives into the research! I also deeply appreciate Layne’s oft-repeated mantras: 1) Facts don’t care about your feelings 2) That which can be asserted without evidence can be dismissed without evidence.

Dude, I am hooked to your channel! I can't wait till you tell me one day if sweeteners are unhealthy or not. Till then, I will blast my system with this stuff

Coke zero is the peak achievement of the scientific community. FTA.

As someone who has lost almost 60 lbs within the past 5 months, I can pretty much thank artificial sweeteners for helping me keep myself satisfied with less/zero calorie alternatives (both more natural options like monkfruit and artificial ones like Splenda.) If I had to point to one culprit that made me go up to 300 lbs over the past two years, I think it would have to be the amount of sweet tea I drank on a daily basis. I know this is anecdotal and I can't say definitively that it was as simple as that alone; however, I know I used to drank 30 - 40 oz of sweet tea on a daily basis, and that is somewhere around 320 - 450 extra calories every day that I never considered to be an issue. Once I stopped drinking that stuff and made other low calorie switches to my normal meals--and I even curbed my tea intake to just one 20 - 25 oz just to help with my teeth staining--my weight has been melting off without too much hassle on top of increasing my weekly exercise and portion control.

Found you on the Huberman podcast and so happy I did. I love the way you think and explain. Appreciate it.

Been using liquid Splenda for several years and more recently liquid Splenda monk fruit. Never had any problems with yearning for food containing actual sugar as so many claim results from using no-sugar sweeteners. Have lost more than 60 lbs in conjunction with keto and IF. And my last blood and urine test results were the best in a couple of decades. So I'm fine with taking the opinion that no-sugar sweeteners have been a blessing for me.

Great breakdown layne

Every time there is unsupervised work being done by subjects, it turns out that most subjects lie, make up data, forget to do it... In one study I set up, we asked patients if they lied/made-up data/forgot at the end of the data collection, pretending that it wouldn't matter if they did and behaving like bros. More than half did the measurements wrong and made up the data to cover their mistakes. That is huge.

I feel like whenever I see the term gut micro biome, I think of how big and vast the ocean on planet earth is, and how little we know, in depth, about all the creatures that may exist in it

As someone doing their PhD in microbiome research, I can say for sure that increases in SCFA-producing bacteria is almost always considered a plus. SCFAs, especially butyrate, are extremely beneficial when it comes to intestinal barrier integrity and reduced inflammatory tone.

As a person who never liked the taste of diet soda, eating or drinking anything with non nutritive sweetners was a shock to my system - I'm glad I watched this video and have a better understanding of what is happening - thanks Layne for making published research understandable

thanks for breaking down the study, and your criticism was very interesting and which teaches us a lot about the limitation of individual studies

18:55 most important part of this video. The study is legit. The interpretation by people with out this sort of critical thinking (aka the media) is what will be dangerous.

Really good talking points! That stress response explanation makes major sense

Especially for diabetics, sugar substs helps to reduce carbohydrates.

I have been taking in enough artificial sweetener to satisfy an elephant on a daily basis for 17 years now. I am lucky to be alive.

One of the few voices of reason in nutrition. Thanks man