Benefits & Risks of Peptide Therapeutics for Physical & Mental Health

I'm 42, have been prescribed benzos for insomnia since 14. my life was falling apart. Your first 3 episodes on sleep allowed me to fix a life long problem in days. No drugs, no benzos, its been 3 years. You saved me from the depths of insanity. I have recommended you to countless friends and will continue to do so. I owe you a debt of gratitude. Thank you.

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Dear Dr. Andrew I don't think you will read this comment, but I wanted to tell you that thanks to your videos, here in the Ukraine I am learning English and new interesting information. Thank you very much.

This man is giving us all a World Class education right over here!

00:14 🧬 Peptides are gaining attention for therapeutic use, beyond GLP1 analogues, focusing on tissue healing, longevity, and vitality. 02:32 💊 Peptides are categorized into prescription, gray market, and black market, with safety concerns increasing outside prescription use. 07:50 🧪 Peptides are small proteins made of amino acid chains, often exhibiting pleiotropic effects, influencing various cellular processes. 11:07 🧠 Therapeutic peptides rarely have single-target effects, commonly affecting multiple pathways and cell types. 14:34 🚑 It's crucial to obtain therapeutic peptides through a board-certified physician to ensure safety and efficacy, avoiding risks associated with gray and black market sources. 15:02 ⚕ Therapeutic peptides can be utilized for tissue rejuvenation and repair, impacting muscle, connective tissue, and gut health. 21:38 💪 BPC-157, a therapeutic peptide, promotes tissue repair through stimulating angiogenesis, encouraging fibroblast migration and growth, aiding in injury recovery. 22:20 🩺 Gastric juices historically used for tissue preservation and repair, even in gruesome scenarios like preserving severed fingers. 23:44 🧪 BPC-157, a peptide compound found in gastric juices, shows promise in tissue preservation and rejuvenation, but its mechanism of action outside the gut remains somewhat mysterious. 26:17 ⚠ Limited human clinical studies on BPC-157 make its effectiveness and optimal delivery method uncertain, despite anecdotal evidence and animal studies suggesting potential benefits for tissue repair. 28:48 💊 BPC-157 has a high safety profile, but caution is advised due to potential tumor growth risks associated with its mechanism of action involving upregulation of growth hormone receptors. 32:16 🚫 BPC-157 may pose risks for individuals with tumors due to its promotion of angiogenesis and vascular growth, potentially accelerating tumor growth. 36:53 💉 Thymosin beta-4 (TB-500) and thymosin beta-4 (Tβ4) are peptides gaining attention for tissue rejuvenation and repair, particularly in conjunction with BPC-157, but their efficacy in humans remains uncertain without clinical trials. 41:04 💪 Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) play crucial roles in metabolism, muscle growth, fat loss, and overall vitality, with GH secretion decreasing with age. 44:02 💉 Growth hormone and IGF-1 have various effects related to youthfulness, vitality, and energy, but indiscriminate growth may pose risks like tumor growth. 47:07 🏥 Category one peptides, such as CJC-1295, tesamorelin, and sermorelin, are FDA-approved and more thoroughly tested in humans for stimulating growth hormone release. 49:13 💤 Side effects of peptides like tesamorelin may include altering sleep patterns, potentially reducing REM sleep. 53:54 💊 Type two peptides, like ipamorelin and hexarelin, increase growth hormone release by mimicking or stimulating ghrelin, which can also increase hunger and anxiety. 56:41 ⚠ Hexarelin, while potent at increasing growthhormone, can lead to receptor desensitization and other adverse effects like increased prolactin levels. 01:00:38 🤝 Combining different peptides in cocktails may offer benefits but requires careful dosing and supervision by experienced healthcare providers. 01:03:52 ⚠ Augmenting the growth hormone pathway, whether by synthetic growth hormone or peptides, increases the risk of tumor growth and cancer due to the indiscriminate nature of growth hormone and IGF-1. 01:04:21 💊 Peptides like growth hormone secretagogues have potential benefits like faster injury recovery, but there's a trade-off between benefits and risks. 01:05:02 ⚠ Considerations for taking growth hormone secretagogues include age, potential tumor risks, using minimal effective dose, and assessing clinical need. 01:06:01 🧬 Peptides for longevity like Epitalon mimic naturally occurring peptides and show potential benefits in animal studies for suppressing tumor growth and adjusting circadian rhythm. 01:09:21 🌞 Peptides stimulating the melanocortin system, like Melanotan, can darken skin and potentially improve mood and libido, mimicking the effects of sunlight exposure. 01:20:55 💡 Kisspeptin peptides stimulate hormone pathways related to vitality and libido, potentially impacting mood, energy, and reproductive function, but their effects are st

Omg to see research on BPC-157 from my little ol med school from Croatia quoted on Huberman .... I'm having a moment lol

Dr Huberman, thank you so much for the contributions you have made to informing and educating the public. I am a full-time student suffering from ADHD and many of your episodes have helped me manage my condition: focusing my eye sight without blinking helps me immediately regain focus, taking phosphotidyl serine has helped me with working memory, hyperactivity and executive dysfunction. I have cut down my alcohol intake, I have read the book and followed the advice of Anna Lembke, I can handle anxiety better with your breathing protocol, and I could give so many more examples of how your podcast has helped me. So thank you so much for that and THANK YOU for your interest in science 😊😊

Thank you for this video and all of your videos. There is a reason why you created this platform… It’s needed. KEEP GOING ❤

I've never heard of him till the controversy. Now I'm subscribed. Anybody that the media tries to smear I find out what they have to say. It's usually the truth or something beneficial to you. It's a good barometer for figuring out who you should listen to.

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You helped me to overcome my bad habits and I learned how to focus gratefully to your videos. Thank you for your work! Keep going. Your loyal follower, Julia.

Dr. Andrew Huberman, thank you for another info-packed episode. You are one of the greats of our time...way out in front as a scientist and teacher. Your contribution is felt around the world and it’s enormous! My health has improved so much thanks to what I have learned here. ❤️

Just wanted to show my support. Thanks for everything dr. Huberman! Your work is priceless!

¡Hola Profe! Just wanted to express my deepest gratitude for educating us every single week.Thank You for Your hard work and care for all of us.

I wasn’t familiar with how peptides work. As usual I learned a ton which is why I return to this channel again and again. Thanks so much, Andrew and your team (I am assuming you have a team). Your dedication & commitment to bringing easy-to-comprehend science education to the masses does not go unnoticed! 🙏

I'm here to support this man and to say I really really don't care about his personal life. I'm here for good and medically proven advice. The fact that people who never ever watch any of his podcasts are trying to deter his audience for issues that are unrelated and not their or our business is infuriating.

Huberman pretty much saved my live as in giving me selfguidance and effectivness after bad injury. Pretty exicited for this one. Was planning to try Oxytocin with my wife, so as always perfect timing. Thanks my man

I fixed my insomnia because of your sleep protocol. Understanding why we need sunlight helped me go outside during different daytime and it definitely helped. I am not going to be budged by these so-called accusations targeting you. I understand so much about myself, my struggles, and my behaviors because of you, and can confidently say that you have changed my life in a significant way. I'm very interested in neuroscience now and if I decide to pursue my Ph.D. in NS, it will be because of you. Thank you, Mr. Huberman. I'm grateful to you.

Thank you for the work you put in to these podcasts

I’ve been giving my dog bpc-157 and it’s helped her tremendously. She developed digestive issues in her old age making her nauseous, stomach bloated, sometimes throwing up after eating. Since giving her bcc-157, her condition has improved dramatically. Her stomach is no longer bloated, she’s not nauseous, and hasn’t thrown up. She also doesn’t moan anymore if I pick her up.