Ben Bikman, PhD | Reversing Insulin Resistance | The Metabolic Link Ep.9

Published 2023-03-21
On this week’s episode of The Metabolic Link, Dr. Dominic D’Agostino is sitting down with world-renowned metabolic scientist, Ben Bikman, PhD, to explore the ins and outs of insulin resistance, Type 2 Diabetes Mellitus (T2DM), and ways to manage, and even reverse, both.

In this discussion, Dr. Bikman makes a case for why testing fasting insulin should be a part of the diagnostic and treatment equation when addressing T2DM, the difference between pathological and physiological insulin resistance, and how insulin therapy affects metabolic physiology in T2DM. Dr. Bikman explains that while insulin is necessary for healthy living, it can elicit significant and harmful changes in tissue metabolic function when chronically elevated. Dr. D’Agostino and Dr. Bikman also dive into the relationship between triglycerides and insulin, and some of his latest research in the lab.

Dr. Ben Bikman has a Ph.D. in Bioenergetics and completed a postdoctoral fellowship with the Duke-National University of Singapore in metabolic disorders. His research focus is to elucidate the molecular mechanisms that mediate the disruption that causes and accompanies metabolic disorders, such as obesity, type 2 diabetes, and dementia. Driven by his academic training, he is currently exploring the contrasting roles of insulin and ketones as key drivers of metabolic function. He is a highly accomplished scientist with numerous publications in high impact journals and international presentations.

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All Comments (21)
  • I was able to reverse pre diabetes, PCOS, insulin resistance and fatty liver with diet change. I stopped eating carbs. All on my own because my doctor was more interested in medicating me instead of educating me on metabolic syndrome and the importance of diet. I learned how to eat watching YouTube videos. I wish doctors were better educated in nutrition instead of just keeping patients dependent on pharmaceuticals.
  • @bazo0
    Ben Bikman is a treasure. Loved that talk. Reversed prediabetes, lost 90lbs, a dozen other improvements like eczema/brain fog/depression/social anxiety resolved etc. Beef, butter, bacon, eggs, 0carb hard cheese, bone broth, 1 year so far. Got a lot of chicken and fish early on, with added butter. Now mostly steak and eggs and eggs and steak. I don't care if I am wrong about everything and die instantly at some point, I prefer feeling good for as long as I am alive, rather than living to 100 and be on meds and in a nursing home for 40 years, or die on cancer like most of my family due to carb addiction. Eat real food with 1 ingredient.
  • @vthirteen
    There comes a time when, after reading and watching so much on the subject of metabolic health, you have to rely on information from ‘expert sources’ and it is evident Mr Bikman is one of the few at the top of his game. Great talk from both gentlemen.
  • Thank God for Dr. Bikman! I am 58 years old and have been. T2D for 25 years. I read the doctor's book, Why We Get Sick, twice. In 6 months, the information in that book has helped me reduce my insulin usage by 70% and my A1C is down from 10.5 to 7.2 and I have lost 30 lb. I'm so thankful for this new information. ❤ Please keep spreading the word on insulin resistance to help more people.
  • @bigbaldme
    I love that Dr Bikman only says what he actually knows. If he doesn’t know he doesn’t invent. I trust him!
  • @denisedecker7330
    This guy can pick up on any lead by a host. He is not full of himself as some of the pioneers in this field acting like they have a patent on this information. He's a treasure!
  • @joyperry8310
    Ben Bikman is just fabulous. I could listen to him all day long. What a great source of such important information!!
  • I love Dr Bikmans book "Why We Get Sick." This is exactly what happened to me over the last 25 years. I'm working on reversing my insulin resistance/ Type2 diabetes with low carb and IF. It works. I have already reduced my insulin injections and medications by over 60%
  • @TheAndyb1968
    Dr. Bikman is such an excellent teacher. I learn so much from him.
  • @24bellers20
    I’ll start at the beginning. @28 I developed hypertension from literally nowhere. I was running 10km a day. I had scans, echoes, bloods, stress test, v max. Nothing showed any issues. Fast forwards to 2022,I am now 66. I went carnivore. My Bp is now lowering. I have come off 2 meds onto 1. At the rate I am improving it looks as though I will be med free by the end of the year. All along it must have been an insulin/ glucose metabolic issue. No one tested my insulin only my glucose, and because that sat between 4.7 and 6 I was deemed to be in good health. These guys have changed my life and I thank them for that so much. I share every podcast and will send this to my GP practice.
  • This was a great pairing of question and answer on this subject. Dr Bikman is a master at simplifying complex information in a practical everyday people approach. Thank you.
  • My new soon to be old Dr. Refuses to prescribe me a CGM because she doesn’t want me to obsess over the numbers and wants me to follow the Diabetes association’s dietary guidelines. I have been doin ketovore since Feb.25th and have lost weight, lowered my daily blood glucose, and A1C with no thanks to her!
  • I started low carb in 2018 after learning I was prediabetic, at age 71. My PCP had merely circled my fasting glucose number of 117, and said my AST was high, at 48. I went home and looked it up and decided I was prediabetic. At least. He had never run A1C on me. Since then it has been like pulling teeth to have fasting insulin run. Last checkup I asked what my A1C was, he replied my fasting BS was 99 so need to check it. OMG. And he is proud of my health, saying I'm his best patient. Carnivore here, no thanks to him. I looked up the lab report and ketones were "+1".
  • 2 amazing experts! Mind blowing amount of information. I’m going to have to listen again to absorb all of the data!!
  • @pix6136
    Great talk. Having been diagnosed with HBP in my 30's tgen NAFLD in my 40's then Graves Disease in 50's with half thyroid taken plus dealing with swinging obesity periods abd now in my 60's i've got the brain fig, lethargy, protruding stomach, skin problems, varicose veins. I've just started realising its probably leaky gut and insulin resistance all along. I've now started intermittant fasting but after listening to your talk and other doctors i'm going to switch to wholefoods, no sugar and flours and build to a 36 hour fast once a week to try and get on top of my symptoms . I feel 82 instead of 62 . Thanks for your insights
  • @debbieb1482
    Fantastic information! This has helped me figure out some of the things in managing my health goals. I'm doing very low to no carbs and eating one meal, mainly meat (beef and pork) in the evening. I needed to lose weight, bring down my A1C, lower my BP, etc. I'm finally being more successful at it and controlling my carb cravings. Some of what you have both said here has explained in part what I've been learning in practice. I enjoy listening to the two of you break all of this down. Thanks!
  • @tony3998
    I did cured my type2 diabetes in 6 months I started at 8.7 A1c and now I'm on 4.6 I started with intermittent fasting 2 meals a day, and low carbs 50g a day and stopped sugar and processed food LCHF
  • Thank you so much for pointing out that in type 2, insulin production might be insulin insufficient but it does not "Burn Out" I coach LADA (type 1 in adults) and so very many of them were misdiagnosed as type 2 for a significant time, some for years. It is far more plausible (in many cases) where those type 2s who "burn out" were never type 2 at all.